Two weeks in, injuries shake up Week 3 fantasy plans. Jake Browning steps in for Joe Burrow and offers a viable high-end QB2 floor in superflex formats, aided by elite Bengals weapons but with turnover risk. Mac Jones emerges as a Week 3 streamer in Kyle Shanahan’s system if Purdy remains sidelined, while Cooper Kupp returns as a steady WR3 floor in PPR for Seattle. These waiver moves shape Week 3 lineups, especially in deeper leagues.

Consider Browning in all superflex leagues, Jones in deeper 1-QB or 12+ team formats, and Kupp in every format as Seattle’s possession security blanket grows. The Brock Purdy timeline, Cardinals’ defensive struggles, and Seattle’s pass-heavy approach add nuance to Week 3 decisions and DFS rostering.

Brock Purdy may return for the 49ers' home game against Arizona, with a turf-toe recovery that could allow limited practice this week. If he suits up, SF’s fantasy upside remains bright with Kittle and Jennings as primary targets and Tonges lurking as a Week 1 hero. In Week 2, Mac Jones orchestrated a surprising SF debut with 279 yards and 3 TDs, a sign the backup QB path can still produce fantasy dividends. Arizona starts 2-0 but hasn’t topped 300 yards in a game, hinting at potential regression as SF’s defense clamps down.

Week 1 saw Purdy deliver a late TD pass to Tonges, while Seattle loomed as the opener. The Cards’ offense, led by Kyler Murray, has been productive enough to win without explosive totals. The Week 3 clash will test Purdy’s health and the 49ers’ depth, with implications for Kittle, Jennings, Tonges and the backfield in fantasy lineups.

Brock Purdy’s Week 3 availability is the central question for the 49ers as toe and shoulder issues collide with a home matchup against Arizona. A limited practice window keeps Purdy in play, but San Francisco has Mac Jones ready if Purdy can’t go. The team also navigates McCaffrey’s calf/rest schedule, Bosa and Williams’ vet days, and Jennings/Juszczyk injuries, while Ben Bartch lands on IR and rookie Connor Colby steps in at left guard.

Fantasy managers should monitor Purdy’s status; if he starts, the offense maintains a reasonable floor with potential upside in a plus matchup. If Jones starts, San Francisco shifts to a more conservative plan with McCaffrey as the centerpiece and Colby stabilizing the line for a run-focused attack against Arizona.

Brock Purdy's turf toe has him limited at practice with a real chance to play Week 3 against Arizona. Shanahan will gauge reps to reintegrate him, a step SF needs after a banged-up 2024 and George Kittle being on IR. Mac Jones filled in Week 2 and SF won, but Purdy's health remains the keystone for fantasy value and divisional plans.

If Purdy suits up, expect SF to blend quick passes with a steady run game, keeping targets spread but leaning on McCaffrey and the receiving corps. If he sits, Jones or a scaled-back script could shift the offense, lifting or lowering fantasy upside across the lineup as SF guards Purdy's timetable.

The Week 3 matchup vs Arizona becomes a litmus test for Purdy's timetable and the offense's staying power as SF navigates a tough division; the team’s depth and return timeline will shape weekly fantasy projections far beyond this week.